For patients taking multiple medications,

LIVALO metabolism offers a reduced potential for certain drug interactions1-3

Drug-drug interactions are a potential risk factor for clinically significant side effects3,4

  • ~75% of all drugs metabolized depend on CYP450 (CYP) for their metabolism, including most commonly prescribed statins5-8
  • As such, co-administration of other drugs with certain statins may interfere with statin metabolism and have the potential for clinically significant drug interactions4,5

LIVALO is metabolized differently than most statins and is not dependent on CYP450 (CYP)1

  • LIVALO is predominantly metabolized via a non-CYP pathway and is only minimally metabolized via CYP5
  • Based on this, LIVALO, in combination with most drugs, has a reduced potential for certain drug interactions1-3
    • The principal route of LIVALO metabolism is conjugation with glucuronic acid via liver UGTs with subsequent formation of pitavastatin lactone

LIVALO was studied with CYP-dependent medications with no clinically significant interactions noted

No dose adjustment of LIVALO is required or recommended with1:

  • Amlodipine/diltiazem LA
  • Itraconazole
  • Warfarin: does not prolong PT/INR*
  • Enalapril
  • Digoxin
  • Protease inhibitors:
    • Atazanavir
    • Lopinavir/ritonavir
    • Darunavir/ritonavir

CYP=cytochrome P450. UGT=uridine 5'-diphosphate (UDP) glucuronosyltransferase.PT=prothrombin time. INR=international normalized ratio.

*

PT and INR should still be routinely monitored.

References:

  1. LIVALO [prescribing information]. Montgomery, AL: Kowa Pharmaceuticals America, Inc.; November 2016.
  2. Neuvonen PJ. Drug interactions with HMG-CoA reductase inhibitors (statins): the importance of CYP enzymes, transporters and pharmacogenetics. Curr Opin Investig Drugs. 2010;11(3):323-332.
  3. Corsini A, Ceska R. Drug-drug interactions with statins: will pitavastatin overcome the statins’ Achilles’ heel? Curr Med Res Opin. 2011;27(8):1551-1562.
  4. Huang SM, Temple R, Throckmorton DC, Lesko LJ. Drug interaction studies: study design, data analysis, and implications for dosing and labeling. Clin Pharmacol Ther. 2007;81(2):298-304.
  5. Guengerich FP. Cytochrome P450 and chemical toxicology. Chem Res Toxicol. 2008;21(1):70-83.
  6. Lipitor (atorvastatin) [prescribing information]. New York, NY: Pfizer, Inc.; June 2017.
  7. Zocor (simvastatin) [prescribing information]. Whitehouse Station, NJ: Merck & Co., Inc.; March 2015.
  8. Statin Market TRx by Year. Symphony Health Solutions data as of the end of October 2015.

Stock up with LIVALO samples

Ordering samples of LIVALO is easy.

Download, complete, and sign the LIVALO sample request form.

Fax the completed form to
1-334-272-6034. Please allow 7-10 days for delivery.

Help your patients save with the LIVALO® Savings Program

If eligible, your patients may be able to pay as little as $18 a month for their LIVALO refills.*

*

Certain rules and restrictions apply. Please see eligibility criteria, along with offer terms and details, on the LIVALO® Savings Card.

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