For patients with HIV,

LIVALO effectively lowers LDL-C with no contraindications or dose limitations when prescribed with HIV protease inhibitors*1,2

  • Co-administration of LIVALO with atazanavir, lopinavir/ritonavir, or darunavir/ritonavir did not result in clinically significant changes in the AUC or Cmax of LIVALO1
  • Based on its metabolism, LIVALO may have reduced potential for clinically significant drug interactions mediated by the CYP450 system1,3,4

The FDA issued contraindications and dose limitations for most statins when used with HIV protease inhibitors†2

FDA statin-prescribing recommendations for concomitant HIV protease inhibitor therapy‡2

The Infectious Diseases Society of America also cautions on the use of statins with HIV protease inhibitors5

  • Some statins can have potentially serious drug-drug interactions with HIV protease inhibitors, resulting in contraindications or dose limitations5
  • Unlike other commonly prescribed statins, LIVALO and Pravachol® (pravastatin) do not have contraindications or dose limitations when prescribed with HIV protease inhibitors1,5,6
  • In head-to-head studies, LIVALO demonstrated statistically superior LDL-C reductions vs Pravachol® (pravastatin) in both HIV-positive and HIV-negative patients with dyslipidemia1,7-9

Pravachol is a registered trademark of Bristol-Myers Squibb Company.

AUC=area under the curve. Cmax=maximum concentration observed.

*

LIVALO has only been evaluated with certain HIV protease inhibitors.

HIV protease inhibitors are a common component in highly active antiretroviral therapy (HAART), a complex drug regimen used to treat patients living with HIV.

Chart is modified from FDA statin-prescribing recommendations for concomitant HIV and hepatitis C virus therapy. No head-to-head studies were performed with the statins to determine dosing limitations or restrictions.

§

Pitavastatin row not highlighted in original FDA chart.

References:

  1. LIVALO [prescribing information]. Montgomery, AL: Kowa Pharmaceuticals America, Inc.; November 2016.
  2. FDA Drug Safety Communication: Interactions between certain HIV or hepatitis C drugs and cholesterol-lowering statin drugs can increase the risk of muscle injury. https://www.fda.gov/Drugs/DrugSafety/ucm293877.htm. Accessed August 11, 2017.
  3. Neuvonen PJ. Drug interactions with HMG-CoA reductase inhibitors (statins): the importance of CYP enzymes, transporters and pharmacogenetics. Curr Opin Investig Drugs. 2010;11(3):323-332.
  4. Corsini A, Ceska R. Drug-drug interactions with statins: will pitavastatin overcome the statins’ Achilles’ heel? Curr Med Res Opin. 2011;27(8):1551-1562.
  5. Aberg JA, Gallant JE, Ghanem KG, Emmanuel P, Zingman BS, Horberg MA. Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2014;58(1):1-10.
  6. Pravachol (pravastatin) [prescribing information]. Princeton, NJ: Bristol-Myers Squibb Company, Inc.; July 2016.
  7. Kowa Research Institute, Inc. A 12-week study comparing pitavastatin 4 mg vs. pravastatin 40 mg in HIV-infected subjects. https://clinicaltrials.gov/ct2/show/NCT01301066. NLM identifier: NCT01301066. Accessed August 11, 2017. Final CSR December 2013. DOF07232015.
  8. Sponseller CA, Morgan RE, Kryzhanovski VA, Campbell SE, Davidson MH. Comparison of the lipid-lowering effects of pitavastatin 4 mg versus pravastatin 40 mg in adults with primary hyperlipidemia or mixed (combined) dyslipidemia: a Phase IV, prospective, US, multicenter, randomized, double-blind, superiority trial. Clin Ther. 2014;36(8):1211-1222.
  9. Stender S, Budinski D, Gosho M, Hounslow N. Pitavastatin shows greater lipid-lowering efficacy over 12 weeks than pravastatin in elderly patients with primary hypercholesterolaemia or combined (mixed) dyslipidaemia. Eur J Prev Cardiol. 2013;20(1):40-53.

Stock up with LIVALO samples

Ordering samples of LIVALO is easy.

Download, complete, and sign the LIVALO sample request form.

Fax the completed form to
1-334-272-6034. Please allow 7-10 days for delivery.

Help your patients save with the LIVALO® Savings Program

If eligible, your patients may be able to pay as little as $18 a month for their LIVALO refills.*

*

Certain rules and restrictions apply. Please see eligibility criteria, along with offer terms and details, on the LIVALO® Savings Card.

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